The work of Dr. Fassano supports new model of autoimmune diseases, using a concept of leaky gut. The intestinal epithelial lining, together with factors secreted from it, forms a barrier that separates you from the environment. If the permeability of the epithelial lining compromised, that allows the passage of toxins, antigens, and bacteria in the lumen to enter the blood stream.
This creates a significant strain on the immune system, since its function is to clear the pathogens. In individuals with a genetic predisposition, a leaky gut may allow environmental factors to enter the body and trigger the initiation and development of autoimmune disease. Here at New York Integrative Rheumatology we pay a lot of attention to a gut health and do a specific testing to determine whether you might have a pathogenic bacteria or fungus overgrowth. Growing evidence shows that the gut microbes is important in supporting the epithelial barrier and therefore plays a key role in the regulation of environmental factors that enter the body. It is hypothesized that modulating the gut microbes can serve as a potential method for regulating intestinal permeability and may help to alter the course of autoimmune diseases in susceptible individuals.
We also want to know if you might have a condition called small intestinal bacterial overgrowth (SIBO). SIBO is commonly presented as abdominal discomfort. bloating. gas pain, indigestion and food intolerance and can be a trigger of autoimmune disease. Should you have symptoms suggesting gut dysbiosis we will test you and treat you since gut health has a direct correlation with the health of Immune system.